The code below demonstrates the problem. This happens with ImageEn 10.3.5
You can load a JPEG file in ImageEnViewOriginal, when you save this file in a new name with 
ImageEnViewOriginal.IO.Params.JPEG_ColorSpace := ioJPEG_RGB;
and you load this file in the other ImageEnViewCopy, the red and blue are converted.
Is this a bug? Or can we work around it. We are planning to upgrade our ImageEN components but this is a show stopper for us.
unit uFormMain;
interface
uses
  Winapi.Windows, Winapi.Messages, System.SysUtils, System.Variants, System.Classes, Vcl.Graphics,
  Vcl.Controls, Vcl.Forms, Vcl.Dialogs, Vcl.ExtCtrls, Vcl.ComCtrls, hyiedefs,
  hyieutils, iexBitmaps, iesettings, iexLayers, iexRulers, iexToolbars,
  iexUserInteractions, imageenio, imageenproc, ieview, imageenview, Vcl.ExtDlgs,
  Vcl.StdCtrls;
type
  TFormMain = class(TForm)
    PanelLeft: TPanel;
    StatusBar1: TStatusBar;
    Splitter1: TSplitter;
    PanelClient: TPanel;
    PanelLeftTop: TPanel;
    PanelClientTop: TPanel;
    ImageEnViewOriginal: TImageEnView;
    ImageEnViewCopy: TImageEnView;
    OpenPictureDialog: TOpenPictureDialog;
    ButtonLoad: TButton;
    ButtonSaveAsAndLoad: TButton;
    procedure ButtonLoadClick(Sender: TObject);
    procedure ButtonSaveAsAndLoadClick(Sender: TObject);
  private
    { Private declarations }
  public
    { Public declarations }
  end;
var
  FormMain: TFormMain;
implementation
{$R *.dfm}
procedure TFormMain.ButtonLoadClick(Sender: TObject);
begin
  if OpenPictureDialog.Execute then
  begin
    ImageEnViewOriginal.IO.LoadFromFile(OpenPictureDialog.FileName);
    ButtonSaveAsAndLoad.Enabled := True;
  end;
end;
procedure TFormMain.ButtonSaveAsAndLoadClick(Sender: TObject);
var
  folder,
  uniqueName,
  extension,
  newFileName: string;
begin
  folder := ExtractFilePath(OpenPictureDialog.FileName);
  uniqueName := TGuid.NewGuid.ToString();
  extension := ExtractFileExt(OpenPictureDialog.FileName);
  newFileName := folder + uniqueName + extension;
  ImageEnViewOriginal.IO.Params.JPEG_ColorSpace := ioJPEG_RGB;  // this causes the invert of red and blue while loading
  ImageEnViewOriginal.IO.SaveToFileJpeg(newFileName);
  ImageEnViewCopy.IO.LoadFromFileJpeg(newFileName);
end;
end.